If the damage is severe, you may have congestive heart failure. Also, you could get lower doses more often instead of larger doses less often. You may be given some combination of these medicines: In severe cases, a heart transplant may be needed. Privacy Policy| doi: 10.2196/15859. So are patients who are treated with both anthracyclines and trastuzumab. By: Joseph Cupolo Posted: Wednesday, March 14, 2018. If you have heart failure because of cancer treatment, you will be treated like other patients with heart failure. Reid E, Suneja G, Ambinder RF, Ard K, Baiocchi R, Barta SK, Carchman E, Cohen A, Gupta N, Johung KL, Klopp A, LaCasce AS, Lin C, Makarova-Rusher OV, Mehta A, Menon MP, Morgan D, Nathwani N, Noy A, Palella F, Ratner L, Rizza S, Rudek MA, Taylor J, Tomlinson B, Wang CJ, Dwyer MA, Freedman-Cass DA. Your heart will also be checked regularly during treatment, when starting different treatments, and after you are done with treatment. Breast Cancer Screening and Diagnosis, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology. Tell your doctor if you any of these symptoms start. Bevers TB, Helvie M, Bonaccio E, Calhoun KE, Daly MB, Farrar WB, Garber JE, Gray R, Greenberg CC, Greenup R, Hansen NM, Harris RE, Heerdt AS, Helsten T, Hodgkiss L, Hoyt TL, Huff JG, Jacobs L, Lehman CD, Monsees B, Niell BL, Parker CC, Pearlman M, Philpotts L, Shepardson LB, Smith ML, Stein M, Tumyan L, Williams C, Bergman MA, Kumar R. J Natl Compr Canc Netw. Arem H, Scott R, Greenberg D, Kaltman R, Lieberman D, Lewin D. JMIR Cancer. Arrhythmias are health problems with the speed or rhythm of the heartbeat. Permissions Requests Section. Targeted therapy drugs that can cause damage to the heart include trastuzumab (Herceptin®), bevacizumab (Avastin®), lapatinib (Tykerb®), sunitinib (Sutent®), and sorafenib (Nexavar®). For breast cancer, sometimes dexrazoxane (Zinecard®) is used to prevent or lessen heart damage caused by doxorubicin or epirubicin. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) are posted with the latest update date and version number. Get the latest public health information from CDC: https://www.coronavirus.gov. Click here to view the NCCN Guidelines Panel Members individual disclosures. If you are still having an issue, please contact us. All rights reserved. R01 CA215134/CA/NCI NIH HHS/United States. History, Request permission to link to NCCN Website, End-User Meta-analysis of association between CT-based features and tumor spread through air spaces in lung adenocarcinoma. Yin Q, Wang H, Cui H, Wang W, Yang G, Qie P, Xun X, Han S, Liu H. J Cardiothorac Surg. HHS If treatment for cardiac toxicity is started early, it is more likely that serious heart damage will be prevented. You will first notice the shortness of breath when you are active. Circulating MicroRNAs as Potential Predictors of Anthracycline-Induced Troponin Elevation in Breast Cancer Patients: Diverging Effects of Doxorubicin and Epirubicin. For example, doxorubicin liposome injection, a liposomal anthracycline, is less toxic than regular doxorubicin. In children (≤ 21 years old at diagnosis) with cancer, the short- and long-term risk of cardiac dysfunction associated with therapeutic exposures, such as anthracycline chemotherapy (eg, doxorubicin, epirubicin, daunorubicin) or use of chest-directed RT. The ASCO guidelines are also focused on cancer survivors primarily, with recommendations focused on prevention and screening only in as much as they are known to affect outcomes in survivors. Besides cell death, other types of cardiac toxicity from cancer treatment include: The chemotherapy drugs that most commonly cause heart damage are anthracyclines.