Let's get into the full Week 3 schedule, starting with a Patrick Mahomes-Lamar Jackson showdown at Arrowhead. One possibility is moving left guard Joe Thuney to left tackle, but that could weaken the line in two spots. Experts weigh in with analysis and provide premium picks for upcoming NFL games.

Matchup rating: 50.6 | Spread: SF -7 (44.5), What to watch for: How will Mason Rudolph perform replacing an injured Ben Roethlisberger as the Steelers' starting quarterback? Matchup rating: 62.2 | Spread: IND -1.5 (47), What to watch for: All eyes will be on Adam Vinatieri to see if the Colts' veteran kicker has figured out the "demons" in his head. We're offering a $100 weekly prize in every format throughout the season, and since you're eligible to play in all three you're never out of the running for great prizes. Read more. ET | Fox Stat to know: The Eagles have allowed 680 yards passing through two games, second most in the NFL.

The ESPN Daily delivers the biggest sports news and moments every weekday. What to know for fantasy: Cincinnati's John Ross is the only player in football with a 50-plus-yard reception in both weeks this season, but opponents have completed just one deep pass (15-plus air yards) against Buffalo this season.

Pick NFL winners each week.  |  Fangio is a first-year head coach, but he beat Rodgers all four times he faced him as the 49ers' defensive coordinator (including two playoff games). -- Courtney Cronin, Bold prediction: Kicker Daniel Carlson, a former Vikings fifth-round draft pick who was cut in 2018, will drill a game winner for the Raiders. And look for Detroit's receivers to have big days against a secondary that has yielded six touchdown passes through two games. Only two other quarterbacks have held the ball longer on average through two weeks than Mayfield, according to NFL Next Gen Stats research. FPI prediction: ARI, 55.9% (by an average of 2.1 points), Matchup must-reads: Kyler Murray has Larry Fitzgerald off to the best start of his career ... Don't overlook Kyle Allen if he faces former nemesis Murray, 4:25 p.m. ET | Fox Matchup rating: 50.9 | Spread: MIN -8 (43.5), What to watch for: Quarterback Kirk Cousins said his future with the Vikings is on the line after one of the worst performances of his career in Green Bay. Even so, Dallas still wins easily. Total ARV is $14,100 Louis-Jacques' pick: Bills 28, Bengals 13 Cimini's pick: Patriots 35, Jets 6 Betting nugget: Kansas City has covered nine consecutive September games. Read more. What to know for fantasy: Patriots RB Sony Michel has scored in each of his past five games in which he got at least 15 carries (playoffs included). Terms of Use Read more.

The Chiefs, who didn't score in the second half of their Week 2 game against the Raiders, are depleted, facing the Ravens without wide receiver Tyreek Hill, left tackle Eric Fisher and potentially running back Damien Williams. Stat to know: Matt Breida has averaged 5.4 yards per rush since start of 2018, the most among running backs, and he has nine rushes reaching 15-plus mph this season -- third in the NFL -- per NFL Next Gen Stats data. Read more. FPI prediction: CHI, 57.4% (by an average of 2.7 points), Matchup must-reads: Redskins' season could hinge on beating Bears ... Bears rally around Eddy 'Dinero' Pineiro, the kicker with swag ... Money for nothing: Redskins not getting much from key investments, Cruz sees Chiefs barely beating Ravens (0:57). Matchup rating: 67.6 | Spread: LAC -3 (49), What to watch for: This game features two of the best receivers in the game in Houston's DeAndre Hopkins and Los Angeles' Keenan Allen. Meanwhile, the Raiders' pass defense gave up 249 yards and a touchdown to Denver in Week 1, and 443 yards and four passing touchdowns to Patrick Mahomes in Week 2. The Smiths go to Green Bay: Preston, Za'Darius thrive with Packers ... No sacks or turnovers? PickCenter: NFL | CFB ESPN Fantasy's Kyle Soppe and ESPN Chalk's Mackenzie Kraemer hand out helpful nuggets as well. Barnwell's case for 16-0, Vikings have 'utmost confidence' in struggling Kirk Cousins, Rookie Josh Jacobs: 'I don't want to be labeled as a soft back', Dalvin Cook carrying Vikings, but challenge is to preserve him for season, Raiders' in-flux secondary taking positives from torching by Chiefs, QB Allen looks like star Bills envisioned, How are the Dolphins handling 0-2? and you're ready to dive into another season of ESPN Fantasy Football, cheat sheets out and sure to prove your drafting skills are on point! See Week 3 rankings.

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