https://doi.org/10.1038/sj.bmt.1705544, DOI: https://doi.org/10.1038/sj.bmt.1705544, Biology of Blood and Marrow Transplantation Higher risk of recurrence post ASCT is associated with less than a complete response to second-line therapy (either by CT scan criteria or by FDG-positron emission tomography [PET]), relapse in a prior radiation field or after combined modality therapy, duration of first remission less than 12 months and higher risk score as described by Hasenclever and Diehl at relapse.3,–8. © 2018 American Society for Radiation Oncology. Despite the success of standard front-line chemotherapy for classical Hodgkin lymphoma (cHL), a subset of these patients, particularly those with poor prognostic factors at diagnosis (including the presence of B symptoms, bulky disease, advanced stage, or extranodal disease), relapse. Geez I'm old, lol, but happy to say that. CHLVPP chemotherapy with involved-field irradiation for Hodgkin’s disease: favorable results with acceptable toxicity. This review summarizes the current data on salvage chemotherapy and HCT strategies used to treat patients with relapsed Hodgkin lymphoma after prior autologous HCT. Abbreviations: n, number of allogeneic transplants; ASCT, autologous stem cell transplant; TRM, transplant-related mortality; PFS, progression-free survival; OS, overall survival. A phase 2 multicenter study of lenalidomide in relapsed or refractory classical Hodgkin lymphoma. My life since NHL has changed. © 2016 by The American Society of Hematology, Copyright ©2020 by American Society of Hematology, Treatment options for patients relapsing after ASCT, Checkpoint inhibitors and immunomodulatory therapy, Mammalian target of rapamycin inhibitors, HDAC inhibitors, and other novel agents in cHL, Role of second ASCT and allogeneic SCT in relapsed cHL, https://doi.org/10.1182/blood-2015-10-671826. The two most important risk factors for TRM and OS were a hematopoietic cell transplant co-morbidity index49 (HCT-CI50) ≥ 1, and myeloablative conditioning. I am impatient and have old, blonde chemo brain.LOL. CR: complete remission, PR: partial response, MR: minimal response, SD: stable disease and PD: progressive disease. A prognostic score for advanced Hodgkin's disease. Oddou S, Vey N, Viens P, Bardou VJ, Faucher C, Stoppa AM et al. Overall survival of 118 patients from date of relapse after autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma. Role of a second transplant in the management of poor-prognosis lymphomas: a report from the European Blood and Bone Marrow Registry. Josting A, Rueffer U, Franklin J, Sieber M, Diehl V, Engert A . Three patients received LACE and ASCT without preceding salvage therapy. Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma: results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG). For patients with relapsed or refractory classical Hodgkin lymphoma (cHL), salvage chemotherapy followed by consolidation with autologous stem cell transplant (ASCT) remains the standard of care. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. High-dose BEAM chemotherapy with autologous peripheral blood progenitor-cell transplantation for unselected patients with primary refractory or relapsed Hodgkin's disease. You are in great hands at Princess Margaret.