2013;369:1681-1690. The sooner you tell them of any problems, the sooner they can suggest ways to help you deal with them. Coiffer B, Thieblemont C, Van Den Neste E, et al. J Clin Oncol. 1994;12:1169-1176. The most common combinations of chemotherapy drugs used to treat NHL are: Other combinations of chemotherapy drugs that may be used to treat NHL are: If NHL does not respond to drugs used in earlier treatments or if it comes back (relapses, or recurs), the following chemotherapy combinations may be used: The central nervous system (CNS) is the brain and spinal cord. 40. About Cancer generously supported by Dangoor Education since 2010. Thieblemont C, Tilly H, Gomes da Silva M, et al. Yan L, Yimamu M, Wang X, et al. Gisselbrecht C, Glass B, Mounier N, et al. Wiernik PH, Lossos IS, Tuscano JM, et al. 11. CCS adapting to COVID-19 realities to support Canadians during and after the pandemic. Rituximab in combination with vinorelbine/gemcitabine chemotherapy in patients with primary refractory or early relapsed T cell rich B cell lymphoma. 2003;27:1097-1099. J Clin Oncol. Chemotherapy may cause side effects because it can damage healthy cells as it kills cancer cells. 2010;28:4184-4190. Cancer. Read about the possible side effects of chemotherapy for non-Hodgkin lymphoma (NHL). Weidmann E, Kim SZ, Rost A, et al. Repeat every 3 weeks for 2–6 cycles (max of 4 cycles if using carboplatin). 35. 2008;26:2258-2263. 2008;93:1829-1836. 2002;3:111–116. 52. Haematologica. The following chemotherapy drugs are often combined to treat NHL: Corticosteroid drugs are often given with chemotherapy to treat NHL. Leuk Res. 2005;75:124-129. 37. Haematologica. In case of CD20-positive B cell lymphoid malignancies the ICE regimen is often combined today with rituximab.This regimen is then called ICE-R or R-ICE or RICE. 14. Pfreundschuh M, Trumper L, Osterborg A, et al. 13. Eur J Haematol. a Inclusion of any anthracycline or anthracenedione in patients with impaired cardiac functioning should have more frequent cardiac monitoring. Diese Zusammenfassung hat im Wesentlichen historische Gründe. You may also receive other treatments. Rituximab-EPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: Results of a phase II study. 1988;71:117-122. A phase I–II study of rituximab, ifosfamide, mitoxantrone and etoposide (R-IME) for B cell non-Hodgkin’s lymphoma prior to and after high-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT). This is called intrathecal chemotherapy. 2008;26:2717-2724. 18. To prevent NHL from spreading to the CNS or to treat NHL in the CNS, drugs are given directly into the spaces containing CSF. Day 1: Rituximab 375mg/m2 IV during each cycle of chemotherapy for up to 8 infusions. Lamy T, Damaj G, Soubeyran P, et al. 28. More than 4,000 eligible non‐Hodgkin's lymphoma patients have been treated with the CHOP chemotherapy as part of 43 different clinical trials reviewed. Blood. Accessed May 24, 2018. © 2020 Canadian Cancer Society All rights reserved. Repeat every 4 weeks until complete response. Martino R, Perea G, Caballero MD, et al. Vacirca JL, Acs PI, Tabbara IA, et al. This means that the drugs travel through the bloodstream to reach and destroy lymphoma cells all over the body. 34. Leuk Lymphoma. 4. Some people have many side effects. Lopez A, Gutierrez A, Palacios A, et al. 1. Persky DO, Unger JM, Spier CM, et al. Br J Haematol. Chao NJ, Rosenberg SA, and Horning SJ. d Rituximab should be included in second-line therapy if there is a relapse after a reasonable remission (>6 mo); however, rituximab should often be omitted in patients with primary refractory disease. Witzig TE, Vose JM, Zinzani PL, et al. 2000;18:3633-3642. Copyright © 2020 Haymarket Media, Inc. All Rights Reserved Other people have few or none at all. R-ESHAP as salvage therapy for patients with relapsed or refractory diffuse large B-cell lymphoma: the influence of prior exposure to rituximab on outcome. 2004;15:511-516. Purroy N, Bergua J, Gallur L, et al. It is usually used to treat non-Hodgkin lymphoma (NHL). High-dose glucocorticoids such as prednisone are combined with cytotoxic chemotherapy in the R-CHOP or dose adjusted R-EPOCH regimens used for non-Hodgkin lymphoma (NHL). Zelenetz AD, Hamlin P, Kewalramani T, et al. Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers. CEPP(B): An effective and well-tolerated regimen in poor-risk, aggressive non-Hodgkin’s lymphoma. J Clin Oncol. Chemotherapy for non-Hodgkin lymphoma can be difficult to cope with. Side effects can develop any time during, immediately after or a few days or weeks after chemotherapy. To view unlimited content, log in or register for free. 2012;97:758-765. Dose-adjusted EPOCH plus rituximab is an effective regimen in patients with poor-prognostic untreated diffuse large B-cell lymphoma: results from a prospective observational study. Die Krankheiten, die unter diesem Oberbegriff zusammengefasst werden, sind sehr verschieden. 33. 51. To make the decisions that are right for you, ask your healthcare team questions about chemotherapy. 1990;76:1293–1298. Details on specific drugs change quite regularly. R-CHOP 14 with or without radiotherapy in nonbulky limited- stage diffuse large B-cell lymphoma. GEMOX-R regimen is a highly effective salvage regimen in patients with refractory/ relapsing diffuse large-cell lymphoma: a phase II study.