Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window), “Clinical pharmacokinetics of isoniazid.”, “Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis.”, “Genetic control of isoniazid metabolism in man.”, “Pharmacokinetics of isoniazid metabolism in man.”. Tell your doctor if you have or have ever had liver disease, if you drink or have ever drunk large amounts of alcohol, or if you are using or have ever abused injectable street drugs. Adults The dose of isoniazid for the treatment of tuberculosis is commonly 4 to 5mg per kilogram body-weight daily given by mouth in single or divided doses up to a maximum of 300mg daily. Information provided on this Web site is neither intended nor implied to be a substitute for professional medical advice. Isoniazid, also known as phthivazide or hydrazid, belongs to the class of organic compounds known as pyridinecarboxylic acids and derivatives. In active tuberculosis it is used together with other antituberculosis medications. [7] This drug class includes rifampicin and rifabutin. Blood and lymphatic system disorders Frequency not known: Agranulocytosis, Aplastic anaemia, Haemolytic anaemia Ear and labyrinth disorders Frequency not known: Deafness, Tinnitus, Vertigo These have been reported in patients with end stage renal impairment Vertigo may be troublesome with doses of 10mg per kg body weight Gastrointestinal disorders Frequency not known: Constipation, Dry mouth Nausea, Pancreatitis acute, Vomiting and other gastrointestinal effects General disorders and administration site conditions Frequency not known: Pyrexia Hepatobiliary disorders Frequency uncommon: Hepatitis Frequency not known: Acute hepatic failure, Liver injury, Jaundice The risk of these undesirable effects increases with age, especially over the age of 35; it may be serious and sometimes fatal with the development of necrosis. [8], Rifapentine induces metabolism by CYP3A4, CYP2C8 and CYP2C9 enzymes. Paediatric population The usual daily dose for children aged three months and above is from 10 up to 15mg per kilogram body-weight daily in single or divided doses. Isoniazid in Kenya Isoniazid in Kenya Isoniazid in Kenya Isoniazid in Kenya Isoniazid in Kenya. matured cheeses), wine, beer and some fish (e.g. Any acidosis is corrected with sodium bicarbonate. Co administration is not recommended. You may need to take other TB medicines in combination with isoniazid. [7], Rifapentine should be avoided in patients with an allergy to the rifamycin class of drugs. Isoniazid is an inhibitor of monoamine oxidase (MAO) and diamine oxidase (DAO), therefore can reduce tyramine and histamine metabolism, causing symptoms such as headache, sweating, palpitations, flushing, and hypotension. To view the price of the drug, click on the brand name. Pms-Isoniazid; Descriptions. [13] Although there are no data available to directly evaluate the carcinogenic potential of CPNP, information available on closely related nitrosamine compounds was used to calculate lifetime exposure limits for CPNP. Drug information provided by: IBM Micromedex. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Description and Brand Names. GENERIC NAME(S): Isoniazid. Isoniazid can inhibit the hepatic metabolism of a number of drugs, in some cases leading to increased toxicity. Medindia's drug directory has currently 3 Brands of Isoniazid listed. Hydra, Hyzyd, Isovit, Laniazid, Nydrazid, Rimifon, and Stanozide. Pharma Professional Services nor anyone connected with this site cannot be held responsible for your actions nor any conditions resulting thereof. 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[13], CC(=O)O[C@H]3[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(\C)C(=O)Nc6c(/C=N/N1CCN(CC1)C2CCCC2)c(O)c5c4C(=O)[C@@](C)(O/C=C/[C@H](OC)[C@H]3C)Oc4c(C)c(O)c5c6O, InChI=1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27+,28+,33-,38-,39+,43+,47-/m0/s1, World Health Organization's List of Essential Medicines, "Rifapentine (Priftin) Use During Pregnancy", "Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB", "Priftin- rifapentine tablet, film coated", "Drug Approval Package: Priftin/Rifapentine NDA# 21024", "Rifapentine Orphan Drug Designation and Approval", "FDA works to mitigate shortages of rifampin and rifapentine", Ethambutol/isoniazid/pyrazinamide/rifampicin, Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim, https://en.wikipedia.org/w/index.php?title=Rifapentine&oldid=976356346, World Health Organization essential medicines, Chem-molar-mass both hardcoded and calculated, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple PubChem CIDs, Articles containing potentially dated statements from 2015, All articles containing potentially dated statements, Articles with unsourced statements from March 2020, Creative Commons Attribution-ShareAlike License, 3{[(4-cyclopentyl-1-piperazinyl)imino]methyl}rifamycin, This page was last edited on 2 September 2020, at 14:09.